---
title: Site-Specific Antibody Labeling | PICO BioScience
description: Achieve consistent and reproducible antibody labeling with PICO BioScience's site-specific technology, ensuring precise control and long-term stability for your applications.
---

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- Solutions
  
    - [Single EV Analysis](https://www.pico-bioscience.eu/ev-analysis?hsLang=eu)
    - [Protein Detection](https://www.pico-bioscience.eu/protein-detection?hsLang=eu)
    - [Antibody Labeling](https://www.pico-bioscience.eu/antibody-labeling)
- The PICO Workflow
  
    - [PICO Technology Overview](https://www.pico-bioscience.eu/technology-pico-bioscience?hsLang=eu)
    - [PIQuant Software](https://www.pico-bioscience.eu/piquant?hsLang=eu)
    - [Instrument Compatibility](https://www.pico-bioscience.eu/instrument-compatibility?hsLang=eu)
- [Resources](https://www.pico-bioscience.eu/resources?hsLang=eu)
  
    - [Application Notes](https://www.pico-bioscience.eu/application-notes?hsLang=eu)
    - [Technical Support](https://www.pico-bioscience.eu/resources?hsLang=eu)
    - [Manuals](https://www.pico-bioscience.eu/resources?hsLang=eu)
- [Company](https://www.pico-bioscience.eu/general-terms-and-conditions-pico-bioscience?hsLang=eu)
  
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# Site-Specific Antibody Labeling Service

### **Controlled. Stable. Reproducible.**

PICO BioScience provides a DNA-based, site-specific antibody labeling technology designed for **maximum reproducibility, stability, and quantitative control**.  
Unlike conventional random conjugation methods, our platform ensures a **defined number of labels per antibody**, enabling consistent performance across batches and applications.

## Why Site-Specific Labeling Matters

Traditional antibody labeling methods often introduce variability due to random attachment sites and uncontrolled label density.  
This results in batch-to-batch variation, altered binding behavior, and limited assay reproducibility.

PICO BioScience eliminates these limitations by controlling **where** and **how many** labels are attached to each antibody molecule.

### Defined antibody-to-label ratio

### Site-specific conjugation on IgG

### Quantitative labeling efficiency calculation

### Long-term stability over years

### Compatible with stabilizers (e.g., BSA)

## How the PICO Labeling Technology Works

Our labeling platform uses a **controlled DNA-based conjugation chemistry** that attaches oligonucleotide labels at defined positions on the antibody.

Each labeling reaction is optimized and quality-controlled to ensure:

- Labeling efficiency \>95%
- Structural integrity of the antibody
- Reproducible performance in downstream assays

The result is a **fully characterized, ready-to-use labeled antibody**, suitable for quantitative applications.

![PICO\_Labeling\_Service-2](https://www.pico-bioscience.eu/hs-fs/hubfs/PICO_Labeling_Service-2.png?width=540&height=540&name=PICO_Labeling_Service-2.png "PICO_Labeling_Service-2")

### Ready to Label Your Antibodies with Quantitative Precision?

Discuss your antibody, application, and labeling requirements with our scientific team.  
We support you from feasibility assessment to delivery of fully characterized reagents.

[Contact us](https://www.pico-bioscience.eu/en/contact-us?hsLang=eu)

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